A simple, precise and accurate zero order spectrophotometric method for the determination of ezetimibe in bulk and pharmaceutical dosage form. The drug shows maximum absorption (λ max) at 231nm in acetonitrile solution and obeys Beer’s law in the concentration range of 9-21 µg/ml. The linearity study was carried out and regression coefficient was found to be 0.9996 and it shows good linearity, precision during this concentration range. The % recovery was found to be 98.95-99.76%. The LOD and LOQ were found to be 0.064 µg/ml and 0.196 µg/ml. The % relative standard deviation (%RSD) was found to be less than 2. According to ICH guidelines the technique has been validated for linearity, precision, accuracy, ruggedness, LOD and LOQ. The developed and validated method can be successfully applied for routine quantification of ezetimibe in bulk and pharmaceutical dosage form.
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